ASSESSMENT OF MAGNITUDE AND ASSOCIATED FACTORS OF NEONATAL SEPSIS AMONG NICU ADMISSIONS AT WUSH

Abstract

Background: Neonatal sepsis is a serious medical condition that can affect newborns, particularly in developing countries. It is caused by an infection in the blood and can lead to significant morbidity and mortality. Several factors can increase the risk of neonatal sepsis, including socio-demographic, maternal, neonatal, and medical factors. The clinical signs and symptoms of neonatal sepsis are often nonspecific, making diagnosis difficult and time consuming. As a result, healthcare providers must rely on a combination of risk factor assessment and diagnostic tests to accurately diagnose and treat neonatal sepsis Objective: - To assess prevalence and associated factors of neonatal sepsis among neonates admitted to NICU of WUSH from June 28 2022- June 28, 2023Methodology: A retrospective documentary review study will be conducted at an institution to evaluate prevalence and associated factors of neonatal sepsis among neonates admitted to the NICU of WUSH between June28 2022- June 28, 2023. The sample size will be determined using a single population proportion formula, and study subjects will be selected using a systematic random sampling method. Data collection tools will be adopted and will be used, and the data will be checked for completeness and clarity before being analyzed using the statistical package for social sciences (SPSS) version 25. Descriptive statistics and binary logistic regression will be employed, and the degree of association will be calculated using odds ratios with 95% CI. A p-value of less than 0.05 will be considered significant for associations between dependent and independent variables Result: The overall prevalence of NNS was 58.1% with MR of 6% from total admission (616) of neonates in the past one year, Being male neonate (AOR=5.5; 95% CI (1.8-16.5)), having history of PROM during the index pregnancy (AOR =6.3; 95% CI (2-19.9)), prolonged duration of labor (AOR=0.06; 95% CI (0.01-0.49)), lower APGAR score at birth (AOR=0.02; 95% CI (0.06-0.61)), more than three days of hospital stay (AOR=0.028; 95% CI (0.007-0.11)).Conclusion: The present study had identified many factors from those neonatal sex, mode of delivery, duration of labor, history of maternal PROM, neonatal comorbidities ,APGAR score, and duration of hospital stay, place of delivery were identified as having strong association for NNS, So measures that reduce preventable causes of above factor need to be taken as to reduce the occurrence of sepsis.