THREE YEAR PREVALENCE TREND ANALYSIS OF RIFAMPICIN RESISTANT PULMONARY TUBERCULOSIS IN BUTAJIRA GENERAL HOSPITAL, SOUTHERN ETHIOPIA

Abstract

Background: Multi-drug resistant TB (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampin, the two most potent TB drugs. Ethiopia is highly afflicted by theTBpandemic, multi-drug resistant TB (MDR TB) and is ranked among the top 30 high TB burden countries worldwide. Objective: To determine three year prevalence trend analysis of rifampicinresistantpulmonary Tuberculosis in Butajira General Hospital.Method: Retrospective study was conducted to determine three year prevalence trend analysis of Rifampicin resistant Tuberculosis by reviewing the MDR TB registration laboratory logbook at Butajira General Hospital from February 2019 - February 2022 GC. For all patients, geneXpert were done for the detection of MDR PTB cases. All the socio-demographic data, year, month and MDR PTB data were collected using a predesigned data collection sheet from April to June, 2022.SPSS version 25 software was used for data analysis.Result: Data of 4196 presumptive TB patients were identified, of which 526 (12.5%) were positivefor pulmonary TB and 3670 (87.5%) were negative for pulmonary TB. Overall prevalence of Rifampicin resistant tuberculosis among the participants was 46(8.9%). MDR-TB was more prevalent in the age group 15–34 years (19,41.3%), age groups 45- 65 years (14,30.4%) andmales ,32(69.6%). In the years from 2019 to 2022, the trend of MDR-TB was 7(15.2%), 23(50.0%) and 16(34.8%) respectively, demonstrating a decreasing trend though inconsistent. Conclusion: The trend of MDR-TB proportion in Butajira, Eastern Ethiopia, is fluctuating in the past three years (2019 - 2022), it increase slightly in the first year and decreased slightly in the last one year. Productive age (15 – 34 and 35 – 45)) groups and males were significantly at the greater prevalence of TB and MDR-TB, highlighting the importance of strengthening sustainable TB care and prevention interventions toward these groups of people