Department of Medical Laboratory Science

URI for this collectionhttps://rps.wku.edu.et/handle/123456789/45812

Department of Medical Laboratory Science

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Author: search.filters.author.Nahom ZelekeSubject: search.filters.subject.Azernet Berbere District

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    The Prevalence and Associated Factors Of Soil –Transmitted Helminthiasis and Drug Efficacy Of Mebendazole For Treatment Of Soil-Transmitted Helminthiasis among Primary School Children at West Azernet Berbere District, Central Ethiopia, 2025
    (Wolkite University, 2025-01-30) Nahom Zeleke
    BACKGROUND: Different types of parasitic worms are responsible for soil-transmittedhelminthes infections. Drug efficacy studies of soil-transmitted intestinal helminthes have notbeen well addressed in different parts of the tropics and subtropics, including the current studyarea.OBJECTIVE: To assess the drug efficacy of soil-transmitted helminthes infection and thefactors that is linked to it in elementary school students in the West Azernet Berbere District,Central Ethiopia.METHOD: Prospective study design involving 354 school children was conducted fromFebruary-April 2024 in the base line survey. Sixty-four study participants were involved in thesecond survey for drug efficacy. A systematic random sampling technique was applied. TheKato-Katz method was used to evaluate stool samples. Senior nurses administered 500 mg ofmebendazole as a single dosage to students who had soil-transmitted helminthes infections.Then, after the redosing regimen, or after 28 days of treatment completion, the drug efficacy ofmebendazole was performed based on the cure rate and egg reduction rate. .The data was codedand entered into EPI data version 3.1 and exported for further analysis to SPSS version 21computer software. The cure rate and egg reduction rate were examined using descriptiveanalysis.RESULTS: A total of five intestinal helminths species were found, with an overall prevalence of19.8% (70/354) (95% CI 18.9-20.0) in the baseline survey. The most common parasites foundwere 36(10.2%), A.lumbericoides 21(5.9%) T. trichiura, 10(2.8%) hookworm, other helminthsfound were Taenia spp. 2(0.6%) and E.vermicularis 1(0.2%). After the redosing, the cure rate ofmebendazole against A.lumbericoides rose from 87.9% in the single dose to 100%; similarly, thecure rate for T. trichiura rose from 84.2% in the single dosage to 100%.The mebendazole curerate for hookworms rose from 77.8% with a single dosage to 100% with a redosing.CONCLUSION: Therefore, the cure rate and egg reduction rate of single-dose and redosingphase of mebendazole is satisfactory to treat Ascaris lumbericoides, Trichuris trichiura andHookworm infections.