WONDOSEN GEREMUUMER ABDULWEHABLIDYA HUKAR2024-03-292024-03-292020-12Background: Health care generates tremendous amount of sharp waste materials as biomedical waste, a waste which has been generated during diagnosis, treatment and immunization of human beings and /or research activities pertaining there to or in the production or testing of biomedical materials. Inadequate management of sharp waste materials can be associated with risk to health students, health care workers, patients, communities and their environment. Management of sharp waste materials is a part of infection prevention in health care setting. Objective: To assess the knowledge and practice towards sharp waste material among graduate health science students in wolkite university, Gurage, Southern Ethiopia; 2020 GC. Methods: Institutional based cross sectional study was conducted in Wolkite University from December 20-23, among 129 graduate health science students who were selected by stratified random sampling technique and allocated to each department proportionally. The data was entered by using SPSS version 20 and the result presented in the form of table, figure and chartto describe variables. Results: From the total population 63.56% of the respondents had a good knowledge and 36.43% had poor knowledge. And 29.45% of the respondents had a good practice , however; 70.54% of the respondents had poor practice.enThesis